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Abstract #3070

Differences in resting state fMRI in rat under five different anesthetics

Jaakko Paasonen 1 , Raimo Salo 1 , Joanna K Huttunen 1 , and Olli Grhn 1

1 Department of Neurobiology, A.I.Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland

Resting state fMRI is an attractive tool in preclinical research, but translational value of results may be hindered by anesthesia. Our aim was to investigate the possible differences in the resting state of rat brain under five different anesthetics. Data were measured from n = 52 rats and analyzed with independent component analysis. Three cortical and one striatal component were chosen for further comparison. Significant spatial and spectral differences were seen between groups in all cortical components, but not in striatal component. Therefore the anesthetic in animal resting state studies should be carefully selected, especially when investigating the cortical networks.

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