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Abstract #3060

Is heart rate variability a hidden factor in resting-state functional connectivity?

Chantal Delon-Martin 1,2 , Hugo Lafaye de Micheaux 1,2 , Sonia Pellissier 1,3 , Amandine Rubio 2,4 , Bruno Bonaz 1,5 , and Sophie Achard 6

1 U836, INSERM, Grenoble Cdex 9, France, 2 GIN, UJF, Grenoble, France, 3 LPPA, Universit de Savoie, Le Bourget du Lac, France, 4 Gastro-entrologie pdiatrique, CHU, Grenoble, France, 5 Hpato-gastroentrologie, CHU, Grenoble, France, 6 GIPSA-Lab, CNRS, Grenoble, France

Aim : Does autonomic nervous system impact on resting-state functional connectivity ? Methods : We acquired the heart rate variability as a measure of ANS simultaneously with rs-fcMRI. We measured the correlation between LF-component of HRV and each region time-course. We measured the HRV impact on the connectivity of each region with all other regions. Results : We evidenced that the HRV correlates negatively with the time-course of brain regions and biases the connectivity measures between brain regions. Conclusion : In rs-fcMRI, the impact of ANS has to be taken into account for proper interpretation of results from group studies.

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