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Abstract #3041

Functional hippocampal networks changes in relation to spatial learning in hemispherectomized rats

Willem M Otte 1,2 , Pascal Bieleveld 3 , Eric van Diessen 2 , Umesh S Rudrapatna 4 , Kees P Braun 2 , and Rick M Dijkhuizen 1

1 Image Sciences Institute, University Medical Center Utrecht, Utrecht, Utrecht, Netherlands, 2 Department of Pediatric Neurology, University Medical Center Utrecht, Utrecht, Utrecht, Netherlands, 3 Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, Netherlands, 4 Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut, United States

Using resting-state fMRI and minimum-spanning tree analysis the functional hippocampal network organization was characterized in relation to the extent of spatial memory, following experimental hemispherectomy in rats. The data sheds new light on patterns of change in functional network organization in the contralateral hippocampus in relation to changes in spatial memory after hemispherectomy. Improved spatial memory after hemispherectomy related to decreased diameter and increased leaf number of the networks minimum-spanning tree, indicating a shift towards a more star-like network. This supports the hypothesis that reorganization of hippocampal neural networks contributes to consolidation of spatial learning and memory after hemispherectomy.

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