Abstract #3030
On the age effect of the BOLD signal in rat fMRI using electrical mystacial stimulation
Shin-Lei Peng 1,2 , Lin-Yi Huang 1 , Sheng-Min Huang 1 , Yi-Chun Wu 3 , Fu-Chan Wei 4 , Chih-Jen Wen 4 , Hui-Yu Cheng 4 , Chih-Hung Lin 4 , and Fu-Nien Wang 1
1
Department of Biomedical Engineering and
Environmental Sciences, National Tsing Hua University,
Hsinchu, Taiwan,
2
Advanced
Imaging Research Center, UT Southwestern Medical Center,
Dallas, TX, United States,
3
Molecular
Imaging Center, Chang Gung Memorial Hospital, Taoyuan,
Taiwan,
4
Department
of Plastic and Reconstructive Surgery, Chang Gung
Memorial Hospital, Taoyuan, Taiwan
In this study, we investigated the age-related change in
the BOLD response to whisker pad stimulation by
including 3- and 9-month-old rats. Results showed that
BOLD responses to a whisker pad stimulus were similar in
the spatial extent, signal changes and hemodynamic
response between 3M and 9M rats. These results indicate
that rodent fMRI studies are feasible in populations
composed of rats aging up to 9-month-old. The further
age-related correlation is not needed in the rodent fMRI
studies.
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