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Abstract #3030

On the age effect of the BOLD signal in rat fMRI using electrical mystacial stimulation

Shin-Lei Peng 1,2 , Lin-Yi Huang 1 , Sheng-Min Huang 1 , Yi-Chun Wu 3 , Fu-Chan Wei 4 , Chih-Jen Wen 4 , Hui-Yu Cheng 4 , Chih-Hung Lin 4 , and Fu-Nien Wang 1

1 Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan, 2 Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States, 3 Molecular Imaging Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan, 4 Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, Taoyuan, Taiwan

In this study, we investigated the age-related change in the BOLD response to whisker pad stimulation by including 3- and 9-month-old rats. Results showed that BOLD responses to a whisker pad stimulus were similar in the spatial extent, signal changes and hemodynamic response between 3M and 9M rats. These results indicate that rodent fMRI studies are feasible in populations composed of rats aging up to 9-month-old. The further age-related correlation is not needed in the rodent fMRI studies.

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