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Abstract #3021

Parametric event related fMRI to investigate non-linear BOLD effects in motor task

Adnan Alahmadi 1,2 , Rebecca Samson 1 , David Gasston 3 , Matteo Pardini 1,4 , Karl Friston 5 , Ahmed Toosy 1,6 , and Claudia A.M. Wheeler-Kingshott 1

1 NMR Research Unit, Department of Neuroinflammation, Queen Square MS Centre, UCL Institute of Neurology, London, United Kingdom, 2 Department of Diagnostic Radiology, Faculty of Applied Medical Science, KAU, Jeddah, Saudi Arabia, 3 Department of Neuroimaging, Institute of Psychiatry, King's College London, London, United Kingdom, 4 Department of Neurosciences, Ophthalmology and Genetics, University of Genoa, Genoa, Italy, 5 Wellcome Trust Centre for Neuroimaging, UCL Institute of Neurology, London, United Kingdom, 6 NMR Research Unit, Department of Brain Repair and Rehabilitation, Queen Square MS Centre, UCL, London, United Kingdom

We have investigated non-linear responses in BOLD using a parametric fMRI power grip motor experiment with five target grip force levels in healthy volunteers. We have demonstrated the ability to detect a complex BOLD response to grip force modulation, affecting different brain regions. The study showed linear and non-linear BOLD responses to varying grip forces in the primary motor cortex and non-linear responses (up to the 4th order) in other motor and non-motor areas. We concluded that BOLD signal and force have a complicated relationship that is far from a simple correlation and further physiological confirmations are warranted.

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