Abstract #3019
Relating cognitive adverse events of antiepileptic drugs to functional network efficiency
Tamar M van Veenendaal 1 , Dominique M IJff 2 , Richard HC Lazeron 2 , Walter H Backes 1 , Paul AM Hofman 1 , Marielle CG Vlooswijk 3 , Anton de Louw 2 , Albert P Aldenkamp 2 , and Jacobus FA Jansen 1
1
Radiology, Maastricht University Medical
Centre, Maastricht, Netherlands,
2
Epilepsy
Centre Kempenhaeghe, Heeze, Netherlands,
3
Neurology,
Maastricht University Medical Centre, Maastricht,
Netherlands
Cognitive adverse events often arise when antiepileptic
drugs (AEDs) are used to treat epilepsy. We hypothesize
that these cognitive problems are accompanied with a
less efficient brain network and test this using graph
theoretical measures on resting-state fMRI data. The
normalized characteristic path length and clustering
coefficient of a low risk group (epilepsy patients
using AEDs associated with mild cognitive side effects)
was compared to a high risk group (patients using AEDs
associated with more severe cognitive side effects). A
significant association was found between risk group the
clustering coefficient of the frontal areas, but not of
the whole brain.
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