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Abstract #3019

Relating cognitive adverse events of antiepileptic drugs to functional network efficiency

Tamar M van Veenendaal 1 , Dominique M IJff 2 , Richard HC Lazeron 2 , Walter H Backes 1 , Paul AM Hofman 1 , Marielle CG Vlooswijk 3 , Anton de Louw 2 , Albert P Aldenkamp 2 , and Jacobus FA Jansen 1

1 Radiology, Maastricht University Medical Centre, Maastricht, Netherlands, 2 Epilepsy Centre Kempenhaeghe, Heeze, Netherlands, 3 Neurology, Maastricht University Medical Centre, Maastricht, Netherlands

Cognitive adverse events often arise when antiepileptic drugs (AEDs) are used to treat epilepsy. We hypothesize that these cognitive problems are accompanied with a less efficient brain network and test this using graph theoretical measures on resting-state fMRI data. The normalized characteristic path length and clustering coefficient of a low risk group (epilepsy patients using AEDs associated with mild cognitive side effects) was compared to a high risk group (patients using AEDs associated with more severe cognitive side effects). A significant association was found between risk group the clustering coefficient of the frontal areas, but not of the whole brain.

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