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Abstract #3009

The Duration and Extent of effects of Neuronavigated Low-Frequency rTMS to Primary Motor Cortex using fMRI in Healthy Subjects

Seong-Uk Jin 1 , Jang Woo Park 1 , Jeehye Seo 1 , Jong Su Baeck 1 , Mun Han 1 , Kyung Eun Jang 1 , and Yongmin Chang* 1,2

1 Department of Medical & Biological Engineering, Kyungpook National University, Daegu, Korea, 2 Department of Molecular Medicine & Diagnostic Radiology, Kyungpook National University, Daegu, Korea

Neuronavigated low-frequency repetitive transcranial magnetic stimulation is known to produce local and interhemisperic neuromodulatory effects on cortical excitability with accuracy in targeting of a given cortical region. However there have been few studies about the duration and extent of neuromodulatory effect in neuronavigated rTMS using functional magnetic resonance image (fMRI). Navigated rTMS on primary motor cortex lead to robust modulation not only at the ipsilateral motor network, but also at the contralateral (unstimulated) hemisphere for more than 20 minutes. Our findings highlight the duration and extent of interhemispheric neuromodulation effects of rTMS with serial consecutive fMRI for the first time.

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