Abstract #2990
Employing Wideband Gradient-Echo MRI to Map the Functional Activation in Rat Somatosensory Cortex with Enhanced Spatial Resolution
Yun-An Huang 1,2 , Shih-Hsien Yang 3 , Tzu-Hao Harry Chao 4 , Edzer L. Wu 5 , Der-Yow Chen 6 , Kuan-Hung Cho 7 , Yeun-Chung Chang 8 , Changwei W. Wu 3 , Li-Wei Kuo 9 , and Jyh-Horng Chen 1,2
1
Department of Electrical Engineering,
National Taiwan University, Taipei, Taipei, Taiwan,
2
Neurobiology
and Cognitive Science Center, National Taiwan
University, Taipei, Taipei, Taiwan,
3
Graduate
Institute of Biomedical Engineering, National Central
University, Taoyuan, Taiwan,
4
Department
of Life Science, National Taiwan University, Taipei,
Taiwan,
5
Institute
of Biomedical Engineering, National Taiwan University,
Taipei, Taiwan,
6
Department
of Psychology, National Cheng Kung University, Tainan,
Taiwan,
7
Institute
of Brain Science, National Yang Ming University, Taipei,
Taiwan,
8
College
of Medicine, National Taiwan University, Taipei, Taiwan,
9
Institute
of Biomedical Engineering and Nanomedicine, National
Health Research Institutes, Miaoli County, Taiwan
Functional MRI (fMRI) has been widely used to discover
the brain functions by examining the T2* weighted
blood-oxygen-level-dependent (BOLD) signals. However,
higher spatial or temporal resolution is urgently needed
for investigating the hemodynamic responses from subtle
neural activities. In this study, single carrier
Wideband MRI with 2-fold acceleration was employing on
the conventional gradient echo sequence (WB-GRE) in rat
fMRI experiments with electrical stimulation to
forepaws. Our preliminary results show WB-GRE could
provide higher spatial or temporal resolution. Also, the
capability of using Wideband technology on fMRI to map
the functional activation with enhanced spatial
resolution has been demonstrated.
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