Abstract #2974
Evaluation of Efficacy of Ketamine for the Treatment of Depression like Phenotype in Mouse Model: A 1 H-[ 13 C]-NMR study
Pravin Kumar Mishra 1 and Anant Bahadur Patel 1
1
NMR Microimaging and Spectroscopy,
CSIR-Centre for Cellular and Molecular Biology,
Hyderabad, Andhra Pradesh, India
The current study investigates the response of ketamine
in behavioral phenotype, and cerebral energy metabolism
in the social defeat model of depression. Mice were
subjected to social defeat (SD) paradigm for 10 days,
and behavioral phenotypes were assessed using sucrose
preference and social interaction. Ketamine was
administered at sub-anesthetic dose in control and SD
mice. Metabolic measurements were carried out by
1
H-[
13
C]-NMR
spectroscopy in conjunction with infusion of [1,6-
13
C
2
]glucose.
Intervention with ketamine improved the sucrose
preference and social interaction in SD mice. Moreover,
the reduced neuronal metabolic activity in SD mice could
recover to control value with ketamine treatment.
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