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Abstract #2972

Increase in sensitivity and signal stability in 17O MRI using a cryogenic RF probe

Mark Aurel Augath 1 , Aline Seuwen 1 , Stefan Zwick 2 , and Markus Rudin 1

1 Inst. for Biomedical Engineering, ETH and University Zurich, Zurich, Switzerland, 2 Bruker BioSpin, Fllanden, Switzerland

The assessment of CMRO2 with 17O-MRI is hampered by a 34000 times smaller signal than that of 1H. In this study we present a cryogenic RF coil for the use of 17O- MRI at 54.27 MHz and make a comparison with a home-built room temperature coil. The 16 mm cryogenic 17O coil was cooled to 30 K and had a Q of 480. Single pulse acquisitions yielded an SNR gain of about 5.3 and a gain in signal stability of more than 8 compared to the room temperature coil. 3D-FLASH images of H217O the mouse brain were acquired of with 1x1x2 mm3 resolution.

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