Abstract #2968
Quantitative Assessment of Neurochemical Profiles in Rat Hippocampus after Short-Term Binge Ethanol Intoxication, Determined Using Ex vivo 1H High-Resolution NMR Spectroscopy
Do-Wan Lee 1 , Jung-Hoon Lee 1,2 , Jung-Whan Min 3 , Sang-Young Kim 1 , Jin-Young Jung 1 , Kyu-Ho Song 1 , and Bo-Young Choe 1
1
Department of Biomedical Engineering, and
Research Institute of Biomedical Engineering, The
Catholic University of Korea, College of Medicine,
Seoul, Seoul, Korea,
2
Department of Radiology,
Kyunghee Medical Center, Seoul, Korea,
3
Department
of Radiological Science, The Shingu University College
of Korea, Seongnam, Seongnam, Korea
The aim of present study was to provide ex vivo evidence
of changes in neurochemical-profiles of rat hippocampus
after 4-day binge ethanol intoxication, using 500-MHz
HR-MAS 1H-NMR spectroscopy. Our results showed that
Glu/tCr and Glx/tCr ratios were significantly higher in
binge-ethanol group than in control group. Our main
findings suggest that glutamate signals and
glutamate-glutamine-cycle in hippocampal region are
particularly sensitive to binge ethanol consumption.
Future studies using a combination of human patients and
in vivo animal investigations, as well as other
neuroimaging approaches, are required to strengthen our
findings and to validate translational component in
binge alcohol intoxicated condition.
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