Abstract #2948
Proton T 2 measurement of Lactate in Brain Tumors at 3T
Akshay Madan 1 , Sandeep Ganji 1 , Zhongxu An 1 , Elizabeth Maher 1 , and Changho Choi 1
1
UT Southwestern Medical Center, Dallas,
Texas, United States
Lactate (Lac) is elevated in tumors and has been
extensively studied because of its potential use in
clinical diagnosis. Lac resonance at 1.31 ppm is
overlapped with lipid signals which are also elevated in
many tumors, thus Lac is often measured using long echo
times. We aim to accomplish precise measurement of Lac
T2 and absolute quantification of its concentration with
corrections for the T2 relaxation effects. We measured
Lac T2 in 18 glioma patients using PRESS at 8 TE's (58 -
268ms). The T2 of Lac was estimated to be
246[plusmn]20ms and was similar between tumor grades and
subtype.
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