Abstract #2946
Quantification of sodium in healthy cervical cord using prior knowledge
Bhavana Shantilal Solanky 1 , Frank Riemer 1 , Xavier Golay 2 , and Claudia AM Wheeler-Kingshott 1
1
NMR Research Unit, Department of
Neuroinflammation, Queen Square MS Centre, UCL Institute
of Neurology, London, United Kingdom,
2
Department
of Brain Repair and Rehabilitation, UCL Institute of
Neurology, London, United Kingdom
In tissue
23
Na
T
2
relaxation
is bi-exponential, resulting in a short T
2
and
a long T
2
fraction.
We have developed
23
Na
MRS protocols (FUSS and FAHS) both based on ISIS for
23
Na-MRS
of the spinal cord. Both sequences result in a single
resonance and similar SNR. A single resonance is often
fit to a single peak, however as the bi-exponential
behavior of sodium in tissue is known this information
could also be factored into the analysis. Here we
investigate mono-exponential, bi-exponential and
combination fits to the data to determine the most
accurate quantification method.
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