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Abstract #2920

The effect of spinning rate variation on lipid resonances in HR-MAS spectra of brain and muscle biopsies

Christina Stahl 1 , Gaelle Diserens 2 , Martina Vermathen 3 , Anna Oevermann 4 , Torsten Seuberlich 4 , Josiane Lauper 1 , Francesca Amati 5 , Chris Boesch 2 , and Peter Vermathen 2

1 Department of Clinical Veterinary Medicine, Bern University, Bern, Bern, Switzerland, 2 Departments of Clinical Research and Radiology, Bern University, Bern, Switzerland, 3 Department of Chemistry and Biochemistry, Bern University, Bern, Switzerland, 4 Department of Clinical Research and Veterinary Public Health, Bern University, Bern, Switzerland, 5 Department of Physiology, Lausanne University, Lausanne, Switzerland

Lipid resonances from mobile lipids can be observed by 1H NMR spectroscopy in multiple tissues and have also been associated with malignancy. The purpose of our study was to investigate the effect of spinning rate variation on the HR-MAS pattern of lipid resonances in non-neoplastic brain and muscle biopsies. We observed a substantial increase in the relative integral of mobile lipid resonances with high spinning rates in non-neoplastic brain tissue biopsies, but only a mild increase in skeletal muscle biopsies.

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