Abstract #2891
Simultaneous measurement of pH, lactate and acetyl-carnitine in skeletal muscle at 7T
Jimin Ren 1 , A. Dean Sherry 1,2 , and Craig R. Malloy 1,3
1
Advanced Imaging Research Center, UT
Southwestern Medical Center, Dallas, Texas, United
States,
2
University
of Texas at Dallas, Texas, United States,
3
VA
North Texas Health Care System, Texas, United States
For a long time, muscle acidification and accumulation
of lactate and acetyl groups have been measured either
invasively by biopsies or noninvasively by separate MRS
techniques targeting on each individual metabolites. The
current study was designed to monitor exercise-induced
changes in pH, lactate and acetyl-carnitine in human
skeletal muscle using a single localized 1H MRS
protocol, with pH reported by carnosine imidazole H4
signal, lactate by its methine signal at 4. 1 ppm and
acetyl-carnitine by its acetyl signal at 2.12 ppm. This
technique provides an easy access to important metabolic
information on multiple pathways in skeletal muscle in
vivo.
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