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Abstract #2889

Improvements on extraction of glutamate and glutamine from GABA editing spectra at 3 Tesla

Jan Willem van der Veen 1 , Stefano Marenco 2 , and Jun Shen 1

1 Magnetic Resonance Spectroscopy Core, NIH, NIMH, Bethesda, Maryland, United States, 2 NIH, NIMH, Maryland, United States

Due to the time constraint of many clinical studies, it is highly desirable to acquire glutamate, glutamine and GABA in a single scan. In this study 141 GABA editing scans were fitted with a basis set of nine metabolite signals simulated by GAMMA with a novel fitting procedure to extract concentrations of glutamate, glutamine, and GABA, taking advantage of the partial spectral separation of glutamate and glutamine by the GABA editing pulse. The high SNR afforded by averaging the large number of spectra also allowed in vivo validation of metabolite chemical shifts and J coupling constants.

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