Abstract #2886
Intracellular Redox State Quantification by 31P MRS measurement of NADH and NAD+ Content during Ischemia/Reperfusion in Perfused Rat Heart
Charlie Yi Wang 1 , Ya Chen 2 , and Xin Yu 1
1
Biomedical Engineering, Case Western Reserve
University, Cleveland, OH, United States,
2
Case
Western Reserve University, Cleveland, OH, United States
Estimation of intracellular redox state using measured
NADH/NAD+ ratio through 31P spectroscopy is an
attractive tool, as alternative methods for direct
assessment are invasive in nature. In this study, we
assess the ability of 31P MRS to quantify the NADH/NAD+
ratio during ischemia/reperfusion injury in perfused rat
heart.
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