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Abstract #2883

Toward field independent quantitative MRS

Anders Tisell 1,2 and Peter Lundberg 1,2

1 Radiation Physics, Department of Medicine and Healths Sciences, Linkping University, Linkping, Sweden, 2 Centre for Medical Image Science and Visualization (CMIV), Linkping University, Linkping, Sweden

Quantitative Magnetic Resonance Spectroscopy (qMRS) provides direct information of the metabolic status of the investigated tissue. Unfortunately, most current approaches do not provide absolute metabolite concentrations. Recently a method was proposed for correction of the water relaxation effects based on the use of quantitative MRI (qMRI). The purpose of the present work was to investigate how large the concentration differences were between such measurements obtained using a 1.5 T system, or a 3.0 T MRI-scanner. Moreover, another aim was to determine to what extent the calibration method would improve the accuracy of the determined concentrations, compared to conventional water scaling. Using qMRI for calibration of the internal water increased the accuracy of the estimated metabolite concentrations significantly. Due to the relative simplicity of such measurements we would recommend such approach whenever absolute metabolite concentrations are required.

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