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Abstract #2864

Multifunctional GdNPs; from probe design to imaging targeting of cancer

Min-Kyoung Kang 1 , Ki-Hye Jung 2 , Soyeon Kim 1 , Hyun-Jeong Jeong 1 , Garam Choi 1 , Eun-Young Jeon 3 , Hee-Kyung Kim 1 , Tae-Jeong Kim 2 , and Yongmin Chang* 1,4

1 Department of Medical and Biological Engineering, Kyungpook National University, Daegu, Korea, 2 Department of Applied Chemistry, Kyungpook National University, Daegu, Korea, 3 Institute Biomedical of engineering, Kyungpook National University Hospital, Daegu, Korea, 4 Department of Diagnostic Radiology and Molecular Medicine, Kyungpook National University Hospital, Daegu, Korea

Amino functionalized silica coated gadolinium nanoparticle (Gd@SiO 2 -NH 2 ) based perfectly soluble potential theranostic agents formulated as Gd@SiO 2 -NHCO-DO3A-BTA. The preparation initially requires the formation of Gd@SiO 2 -NH 2 through self-condensation on the surface of GdNPs in DEG to react with TEOS and APTES. In order to increase solubility as well as used by theranostic agents, Gd@SiO 2 -NH 2 was further conjugated with DO3A-benzothiazole to give the desired product. Gd@SiO 2 -NHCO-DO3A-BTA reveals high MR relaxivity ( R 1 = 8.74 mM -1 s -1 ) and in vitro and in vivo monitoring provides high uptake affinity to tumor. Therefore, this system may be put into a new family of multifunctional theranostic CAs.

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