Abstract #2864
Multifunctional GdNPs; from probe design to imaging targeting of cancer
Min-Kyoung Kang 1 , Ki-Hye Jung 2 , Soyeon Kim 1 , Hyun-Jeong Jeong 1 , Garam Choi 1 , Eun-Young Jeon 3 , Hee-Kyung Kim 1 , Tae-Jeong Kim 2 , and Yongmin Chang* 1,4
1
Department of Medical and Biological
Engineering, Kyungpook National University, Daegu,
Korea,
2
Department
of Applied Chemistry, Kyungpook National University,
Daegu, Korea,
3
Institute
Biomedical of engineering, Kyungpook National University
Hospital, Daegu, Korea,
4
Department
of Diagnostic Radiology and Molecular Medicine,
Kyungpook National University Hospital, Daegu, Korea
Amino functionalized silica coated gadolinium
nanoparticle (Gd@SiO
2
-NH
2
) based
perfectly soluble potential theranostic agents
formulated as Gd@SiO
2
-NHCO-DO3A-BTA. The
preparation initially requires the formation of Gd@SiO
2
-NH
2
through
self-condensation on the surface of GdNPs in DEG to
react with TEOS and APTES. In order to increase
solubility as well as used by theranostic agents, Gd@SiO
2
-NH
2
was
further conjugated with DO3A-benzothiazole to give the
desired product. Gd@SiO
2
-NHCO-DO3A-BTA
reveals high MR relaxivity (
R
1
=
8.74 mM
-1
s
-1
) and
in
vitro
and
in
vivo
monitoring
provides high uptake affinity to tumor. Therefore, this
system may be put into a new family of multifunctional
theranostic CAs.
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