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Abstract #2859

Development of a mucin4-targeting SPIO contrast agent for effective detection of pancreatic tumor cells in vitro and in vivo

Yun-Ming Wang 1 , Shou-Cheng Wu 1 , Chia-Yun Chen 2 , Gin-Chung Liu 2 , and Yu-Jen Chen 1

1 Department of Biological Science and Technology, National Chiao Tung University, HsinChu, Taiwan, 2 Department of Medical Imaging, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan

In search of a unique and reliable contrast agent targeting pancreatic adenocarcinoma, new multifunctional nanoparticles (MnMEIO-silane-NH2-(MUC4)-mPEG NPs) were successfully developed in this study. Mucin4-expression levels were determined through different imaging studies in a panel of pancreatic tumor cells (HPAC, BxPC-3, and Panc-1) both in vitro and in vivo studies. The in vitro T2-weighted MR imaging study in HPAC and Panc-1 tumor cells treated with NPs showed - 89.1 5.7% and - 0.9 0.2% contrast enhancement whereas in in vivo study, it is found to be - 81.5 4.5% versus - 19.6 5.2% (post-injection) respectively.

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