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Abstract #2857

Simultaneous 19F/1H MR Molecular Imaging of Neovascularization in Pulmonary Inflammation

Anne Schmieder 1 , Huiying Zhang 1 , Jochen Keupp 2 , Shelton Caruthers 2 , Samuel Wickline 1 , Elizabeth Wagner 3 , and Gregory Lanza 1

1 Washington University Medical School, St. Louis, MO, United States, 2 Philips Research Laboratories, Hamburg, Germany, 3 Johns Hopkins University, Maryland, United States

Angiogenesis is an important constituent of many inflammatory pulmonary diseases, which is poorly understood. Early neovascular expansion in the lungs in preclinical models and patients is very difficult to assess noninvasively, particularly quantitatively. The present study demonstrated that (19)F/(1)H MR molecular imaging with αvβ3-targeted perfluorocarbon nanoparticles can be used to directly measure neovascularity in a rat asthma model. In rats 7, 14, and 21 days after house dust mite induction of asthma, simultaneous (19)F/(1)H MR imaging at 3T revealed a marked (19)F signal in animals 2 h following αvβ3-targeted perfluorocarbon nanoparticles that was significantly greater than the signal found in the saline treated controls. Our results demonstrate that (19)F/(1)H MR molecular imaging with αvβ3-targeted perfluorocarbon nanoparticles provides a means to assess the extent of systemic neovascularization in the lung. This novel application of dual 1H/19F MR molecular imaging is a clinically translatable approach for noninvasive temporal-spatial assessment of lung angiogenesis, which may provide a better understanding about the role of pulmonary angiogenesis in asthma.

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