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Abstract #2789

A Survey On The Effect Of Antioxidant And Metabolism Modifiers On Lung Metabolism Using Hyperpolarized 13C NMR

Hoora Shaghaghi 1 , Stephen Kadlecek 1 , Mehrdad Pourfathi 1 , Sarmad Siddiqui 1 , Profka Harrilla 1 , and Rahim R. Rizi 1

1 Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, United States

In order to develop a more comprehensive understanding of lung metabolism, we investigated the underlying mechanism of pulmonary metabolic changes in the presence of several notable compounds with a known effect on the biochemical activity of perfused lungs. These compounds included dichloroacetate, a PDK inhibitor; glutathione, an antioxidant and a LDH inhibitor; ascorbate, an antioxidant; dehydroascorbate, the oxidized form of ascorbate; and alpha-lipoic acid, a metabolism modifier. Among these compounds, ascorbate had the most significant effect on PDH flux. In a comparison of the effects, we concluded that the mechanism of ascorbate effect is not due to its antioxidant properties.

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