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Abstract #2771

Kinetic modeling of Hyperpolarized 13C-Pyruvate with Arbitrary RF flip angles in cancer

Naeim Bahrami 1 , Christine Leon 1 , Cornelius Von Morze 1 , Daniel B. Vigneron 1 , and Peder E.Z. Larson 1

1 Department of Radiology and Biomedical Imaging, University of California, San Francisco, California, United States

The primary purpose of this research was to model the kinetics of hyperpolarized (HP) pyruvate and urea to provide improved characterization of cancerous tissues when using arbitrary RF flip angles in dynamic MRSI. This modeling has the ability to detect metabolic conversion and perfusion. The conversion constant of metabolites will increase in tumor with respect to healthy tissues. In this study, we measured T1 values of metabolites including pyruvate, urea, alanine, and lactate in tumor and healthy tissues.

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