Kinetic modeling of Hyperpolarized 13C-Pyruvate with Arbitrary RF flip angles in cancer
Naeim Bahrami 1 , Christine Leon 1 , Cornelius Von Morze 1 , Daniel B. Vigneron 1 , and Peder E.Z. Larson 1
Department of Radiology and Biomedical
Imaging, University of California, San Francisco,
California, United States
The primary purpose of this research was to model the
kinetics of hyperpolarized (HP) pyruvate and urea to
provide improved characterization of cancerous tissues
when using arbitrary RF flip angles in dynamic MRSI.
This modeling has the ability to detect metabolic
conversion and perfusion. The conversion constant of
metabolites will increase in tumor with respect to
healthy tissues. In this study, we measured T1 values of
metabolites including pyruvate, urea, alanine, and
lactate in tumor and healthy tissues.
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