Abstract #2764
In vivo Hyperpolarized 13 C MRS using DPPH as polarizing agent
Emine Can 1 , Mor Mishkovsky 2,3 , Rolf Gruetter 2,4 , and Arnaud Comment 1
1
Institute of Physics of Biological Systems,
cole Polytechnique Fdrale de Lausanne (EPFL),
Lausanne, Switzerland,
2
Laboratory
for Functional and Metabolic Imaging (LIFMET), cole
Polytechnique Fdrale de Lausanne (EPFL), Lausanne,
Switzerland,
3
Department
of radiology, University of Lausanne, Lausanne,
Switzerland,
4
Department
of radiology, University of Lausanne and Geneva,
Switzerland
The present study demonstrates the use of the
hydrophobic radical 2,2-Diphenyl-1-picrylhydrazyl (DPPH)
to polarize acidic metaboilc precursors such as acetic
acid (AcOH) and pyruvic acid (PA). Additional, we
describe a complete atumated protocol that includes
rapid dissolution and transfer, filtration and infusion
of radical free solution to an animal. Polarization
efficiency is quantified and the aplicablitiy to
in
vivo
13
C
MRS study of hyperpolarized AcOH and PA metabolism is
presented.
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