Meeting Banner
Abstract #2760

Absolute quantification of CBF on rodent brain with D 2 O as tracer of 1 H MRI

Chin-Tien Lu 1 , Zi-Min Lei 1 , Sheng-Min Huang 1 , Shin-Lei Peng 1 , Kung-Chu Ho 2 , Chi-Shiun Chiang 1 , Chu-Fang Wang 1 , and Fu-Nien Wang 1

1 Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan, 2 Department of Nuclear Medicine, Chang Gung Memorial Hospital, Linkou Medical Center, Linkou, Taiwan

Due to the characteristic of free diffusion, the local volume of distribution of D 2 O can be assumed as the whole voxel space, and hence make it as a suitable tracer for measuring the CBF. In this study, we aimed to investigate the feasibility of absolute quantification of CBF on rat brain via indirect detection of deuterium by 1H MRI. CBF maps by Single exponential fitting on the washout curve and SVD deconvolution of AIF was showed.

This abstract and the presentation materials are available to members only; a login is required.

Join Here