Abstract #2760
Absolute quantification of CBF on rodent brain with D 2 O as tracer of 1 H MRI
Chin-Tien Lu 1 , Zi-Min Lei 1 , Sheng-Min Huang 1 , Shin-Lei Peng 1 , Kung-Chu Ho 2 , Chi-Shiun Chiang 1 , Chu-Fang Wang 1 , and Fu-Nien Wang 1
1
Department of Biomedical Engineering and
Environmental Sciences, National Tsing Hua University,
Hsinchu, Taiwan,
2
Department
of Nuclear Medicine, Chang Gung Memorial Hospital,
Linkou Medical Center, Linkou, Taiwan
Due to the characteristic of free diffusion, the local
volume of distribution of D
2
O can be assumed
as the whole voxel space, and hence make it as a
suitable tracer for measuring the CBF. In this study, we
aimed to investigate the feasibility of absolute
quantification of CBF on rat brain via indirect
detection of deuterium by 1H MRI. CBF maps by Single
exponential fitting on the washout curve and SVD
deconvolution of AIF was showed.
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