Abstract #2756
Evaluation of flow and permeability weighting in the volume transfer constant obtained by DCE-MRI using contrast media with different molecular sizes
Cheng-He Li 1 , Fang-Hsin Chen 1 , Yu-Shi Lin 2 , Ji-Hong Hong 1,3 , and Ho-Ling Liu 1
1
Medical Imaging and Radiological Sciences,
Chang Gung University, Taoyuan, Taiwan,
2
Diagnostic
Radiology, Chang Gung Memorial Hospital, Keelung,
Taiwan,
3
Radiation
Oncology, Chang Gung Memorial Hospital - Linkou, Taoyuan,
Taiwan
This study aimed to evaluate the different flow versus
permeability weighting in volume transfer constant (K
trans
)
when using contrast media with different molecular sizes
and the extended Tofts model (ETM). Fourteen mice bred
with tumors underwent DCE-MRI with either Gd-DTPA or
Gadomer. The data were analyzed by using both ETM and
the adiabatic approximation to the tissue homogeneity (AATH)
model from which permeability-surface-area-product (PS)
and plasma flow (F
p
) were obtained. This
study found that K
trans
was
more correlated with PS (r
2
=0.72) than F
p
(r
2
=0.09)
when using Gadomer, and more correlated with F
p
(r
2
=0.64)
than PS (r
2
=0.47) when using Gd-DTPA.
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