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Abstract #2756

Evaluation of flow and permeability weighting in the volume transfer constant obtained by DCE-MRI using contrast media with different molecular sizes

Cheng-He Li 1 , Fang-Hsin Chen 1 , Yu-Shi Lin 2 , Ji-Hong Hong 1,3 , and Ho-Ling Liu 1

1 Medical Imaging and Radiological Sciences, Chang Gung University, Taoyuan, Taiwan, 2 Diagnostic Radiology, Chang Gung Memorial Hospital, Keelung, Taiwan, 3 Radiation Oncology, Chang Gung Memorial Hospital - Linkou, Taoyuan, Taiwan

This study aimed to evaluate the different flow versus permeability weighting in volume transfer constant (K trans ) when using contrast media with different molecular sizes and the extended Tofts model (ETM). Fourteen mice bred with tumors underwent DCE-MRI with either Gd-DTPA or Gadomer. The data were analyzed by using both ETM and the adiabatic approximation to the tissue homogeneity (AATH) model from which permeability-surface-area-product (PS) and plasma flow (F p ) were obtained. This study found that K trans was more correlated with PS (r 2 =0.72) than F p (r 2 =0.09) when using Gadomer, and more correlated with F p (r 2 =0.64) than PS (r 2 =0.47) when using Gd-DTPA.

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