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Abstract #2750

Clinical implementation of the Linear Reference Region Model for Dynamic Contrast-Enhanced MRI

Adam Bernstein 1 , Phillip H Kuo 2 , Mark D. Pagel 3 , and Julio Cardenas-Rodriguez 3

1 Department of Biomedical Engineering, University of Arizona, Tucson, AZ, United States, 2 Department of Medical Imaging, University of Arizona, Tucson, AZ, United States, 3 Department of Biomedical Engineering and Arizona Cancer Center, University of Arizona, Tucson, AZ, United States

In this work we analyzed retrospectively DCE MRI data of 17 patients. A comparison between the Linear Reference Region Model (LRRM) and the standard non-linear Reference Region Model (NLRRM) was performed. Clinical DCE MRI can be processed 90-400 times faster with the LRRM than with the NLRRM. The fitting RMSE was systematically 6-7 times higher for the NLRRM compared to the LRRM. Our results suggest that the LRRM is more reliable than the NLRRM when DCE MRI data with low SNR and temporal resolution is available.

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