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Abstract #2727

Comparison of velocity and acceleration selective arterial spin labeling with 15 O H 2 O positron emission tomography.

Sophie Schmid* 1 , Dennis F.R. Heijtel* 2 , Henri J.M.M. Mutsaerts 2 , Ronald Boellaard 3 , Adriaan A. Lammertsma 4 , Aart J. Nederveen 2 , and Matthias J.P. van Osch 1

1 C.J. Gorter Center for High Field MRI, Radiology, Leiden University Medical Center, Leiden, Netherlands, 2 Radiology, Academic Medical Center, Amsterdam, Netherlands, 3 Radiology, VU University Medical Center, Amsterdam, Netherlands, 4 Department of Nuclear Medicine and PET Research, VU University Medical Center, Amsterdam, Netherlands

The aim of this study was to compare AccASL and VS-ASL with 15 O H 2 O PET. Quantitative VS-ASL overestimated GM CBF by 17% compared to PET. A comparable correlation coefficient for Dual VS-ASL and pCASL with PET CBF was found, evaluated voxelwise at the single subject level; AccASL and Single VS-ASL showed lower correlation with PET CBF. The change in the correlation coefficient by including a fraction of PET aCBV was minor for all scans.

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