Abstract #2727
Comparison of velocity and acceleration selective arterial spin labeling with 15 O H 2 O positron emission tomography.
Sophie Schmid* 1 , Dennis F.R. Heijtel* 2 , Henri J.M.M. Mutsaerts 2 , Ronald Boellaard 3 , Adriaan A. Lammertsma 4 , Aart J. Nederveen 2 , and Matthias J.P. van Osch 1
1
C.J. Gorter Center for High Field MRI,
Radiology, Leiden University Medical Center, Leiden,
Netherlands,
2
Radiology,
Academic Medical Center, Amsterdam, Netherlands,
3
Radiology,
VU University Medical Center, Amsterdam, Netherlands,
4
Department
of Nuclear Medicine and PET Research, VU University
Medical Center, Amsterdam, Netherlands
The aim of this study was to compare AccASL and VS-ASL
with
15
O
H
2
O PET. Quantitative VS-ASL overestimated GM
CBF by 17% compared to PET. A comparable correlation
coefficient for Dual VS-ASL and pCASL with PET CBF was
found, evaluated voxelwise at the single subject level;
AccASL and Single VS-ASL showed lower correlation with
PET CBF. The change in the correlation coefficient by
including a fraction of PET aCBV was minor for all
scans.
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