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Abstract #2719

Quantification of cerebral arterial and venous blood T 1 during hyperoxia and hypercapnia

Steffen N Krieger 1,2 , Claudine J Gauthier 2 , Parnesh Raniga 1,3 , Dale Tomlinson 1 , Paul Finlay 4 , Richard McIntyre 1,4 , Robert Turner 2 , and Gary F Egan 1

1 Monash Biomedical Imaging, Monash University, Melbourne, Victoria, Australia, 2 Max-Plank Institute for Human Cognitive and Brain Sciences, Leipzig, Saxonia, Germany, 3 The Australian e-Health Research Centre, CSIRO Preventative Health Flagship, CSIRO Computational Informatics, Herston, Queensland, Australia, 4 Monash Medical Centre, Melbourne, Victoria, Australia

Several inversion recovery MRI sequences have started to use hyperoxic or hypercapnic gas breathing challenges in order to study brain physiology. Increased inhaled concentrations of O 2 and CO 2 can, however, lead to changes in blood T 1 which might influence the accuracy of these techniques. We used an IR Look-Locker EPI MRI sequence to estimate cerebral arterial and venous blood T 1 changes during the inhalation of 7 gas mixtures. Our results indicate that hyperoxic-hypercapnic as well as normoxic-hypercapnic breathing challenges with high CO 2 contents lead to decreased blood T 1 which might be a useful information for eg ASL and calibrated BOLD studies.

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