Abstract #2719
Quantification of cerebral arterial and venous blood T 1 during hyperoxia and hypercapnia
Steffen N Krieger 1,2 , Claudine J Gauthier 2 , Parnesh Raniga 1,3 , Dale Tomlinson 1 , Paul Finlay 4 , Richard McIntyre 1,4 , Robert Turner 2 , and Gary F Egan 1
1
Monash Biomedical Imaging, Monash
University, Melbourne, Victoria, Australia,
2
Max-Plank
Institute for Human Cognitive and Brain Sciences,
Leipzig, Saxonia, Germany,
3
The Australian
e-Health Research Centre, CSIRO Preventative Health
Flagship, CSIRO Computational Informatics, Herston,
Queensland, Australia,
4
Monash
Medical Centre, Melbourne, Victoria, Australia
Several inversion recovery MRI sequences have started to
use hyperoxic or hypercapnic gas breathing challenges in
order to study brain physiology. Increased inhaled
concentrations of O
2
and
CO
2
can,
however, lead to changes in blood T
1
which
might influence the accuracy of these techniques. We
used an IR Look-Locker EPI MRI sequence to estimate
cerebral arterial and venous blood T
1
changes
during the inhalation of 7 gas mixtures. Our results
indicate that hyperoxic-hypercapnic as well as
normoxic-hypercapnic breathing challenges with high CO
2
contents
lead to decreased blood T
1
which
might be a useful information for eg ASL and calibrated
BOLD studies.
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