Abstract #2705
Comparison of Transit Delay Sensitivity between Pseudo-Continuous ASL, Pulsed ASL and Velocity-Selective ASL
Jia Guo 1 and Eric C. Wong 2
1
Bioengineering, UC San Diego, La Jolla,
California, United States,
2
Radiology
and Psychiatry, UC San Diego, California, United States
Transit delay (TD) sensitivity remains the main source
of error in local CBF quantification using ASL. Compared
with PASL and PCASL, Velocity-Selective ASL (VSASL)
labels spins on the basis of flow velocity instead of
location. In theory, VSASL eliminates the gap between
the tagging and imaging regions and the associated long
and heterogeneous TDs. However, it has not been verified
by direct measurement of TDs in VSASL. This study is the
first one to provide direct experimental evidences of
VSASL being insensitive to TD, in contrast to PASL and
PCASL. The averaged TDs of PCASL, PASL and VSASL were
1.280.28s (meanstd), 1.090.28s and 0.240.07s
respectively, via multi-TI experiments.
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