Abstract #2695
Diffusion MRI measurement of muscle fiber size and sarcolemma permeability in normal skeletal muscle growth
Kerryanne Winters 1 , Dmitry S. Novikov 1 , Els Fieremans 1 , and Sungheon Kim 1
1
Radiology, NYU School of Medicine, New York,
NY, United States
We quantified the microstructural changes in normal
skeletal muscle growth using time-dependent DTI combined
with random permeable barrier model (RPBM). A DTI study
with multiple diffusion times was conducted with 4-5
weeks and 10-12 weeks old mice, followed by
immunohistochemistry staining of collagen-IV and
aquaporin-4. Overall, young mice had lower unrestricted
diffusivity, higher membrane surface-to-volume (S/V)
ratio, and lower membrane permeability than the old
mice. Our preliminary results demonstrate that the DTI-RPBM
measures can be used to monitor muscle growth in wild
type mice, and substantiates the potential of using the
DTI-RPBM measures as quantitative biomarkers of myopathy.
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