Abstract #2688
Investigating longitudinal changes in fractional anisotropy in Alzheimers disease using different registration methods
Sila Genc 1 , Christopher Steward 1,2 , Terence O'Brien 3,4 , and Patricia Desmond 1,2
1
Department of Radiology, University of
Melbourne, Parkville, Victoria, Australia,
2
Department
of Radiology, Royal Melbourne Hospital, Parkville,
Victoria, Australia,
3
Department of Medicine,
University of Melbourne, Parkville, Victoria, Australia,
4
Department
of Neurology, Royal Melbourne Hospital, Parkville,
Victoria, Australia
Longitudinal changes in fractional anisotropy in
Alzheimers disease patients were investigated using
three different registration methods. Recent studies
have suggested alterations to the TBSS pipeline in order
to improve the registration process for subsequent image
analysis. Replacing the standard registrations in the
TBSS pipeline in FSL, with ANTs registrations, revealed
minimal differences between the spatial distributions of
FA change in the core white matter tracts within six
months. The consistencies between the standard TBSS,
ANTS-modified TBSS, and study-specific template results
suggests that running the simple TBSS pipeline may be
sufficient for longitudinal analyses in complex
pathologies such as Alzheimers disease.
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