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Abstract #2678

Assessing white matter microstructure in regions with different myelin architecture

Samuel Groeschel 1,2 , Thomas Schultz 3,4 , Gisela Hagberg 2,5 , Uwe Klose 6 , Till-Karsten Hauser 6 , Oliver Bieri 7 , Thomas Prasloski 8 , Alex MacKay 8 , Ingeborg Krgeloh-Mann 1 , and Klaus Scheffler 2,5

1 University Children's Hospital, Tuebingen, Germany, 2 MPI for Biological Cybernetics, Tuebingen, Germany, 3 Institute of Computer Science, University of Bonn, Germany, 4 MPI for Instelligent Systems, Tuebingen, Germany, 5 Biomedical Magnetic Resonance, University Hospital, Tuebingen, Germany, 6 Department of Diagnostic and Interventional Neuroradiology, University Hospital, Tuebingen, Germany, 7 Radiological Physics, University of Basel, Switzerland, 8 University of British Columbia, Vancouver, BC, Canada

In our study we assessed several white matter (WM) imaging protocols in their ability to detect the known differences in myelin architecture between the cortico-spinal tract and frontal WM regions in 18 healthy adolescents. We found that diffusion-weighted imaging parameters and myelin water fraction can give quantitative and most sensitive information about differences in myelin microstructure. From the diffusion parameters, neurite density (NODDI) was found to be more sensitive than fractional anisotropy (FA), underlining the limitation of FA in WM crossing fibre regions. Furthermore, these parameters successfully quantified loss of myelin in 5 patients with Metachromatic Leukodystrophy.

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