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Abstract #2675

Analysis of Normal Appearing White Matter of Multiple Sclerosis by Tensor-based Two-Compartment Model of Water Diffusion

Yasuhiko Tachibana 1,2 , Takayuki Obata 2 , Mariko Yoshida 1 , Masaaki Hori 1 , Michimasa Suzuki 1 , Koji Kamagata 1 , Issei Fukunaga 1 , Kouhei Kamiya 1 , Kazumasa Yokoyama 3 , Nobutaka Hattori 3 , Tomio Inoue 4 , and Shigeki Aoki 1

1 Department of Radiology, Juntendo University School of Medicine, Tokyo, Tokyo, Japan, 2 National Institute of Radiological Science, Chiba, Chiba, Japan, 3 Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan, 4 Yokohama City University Graduate School of Medicine, Kanagawa, Japan

Alterations in water diffusion are found in normal appearing white matter (NAWM) of multiple sclerosis (MS) patients. To detect more minor changes in this condition, a new simple method was designed to assess water diffusion using the two-compartment model combined with diffusion tensor imaging. The method allowed greater detectability of minimal changes in NAWM of MS (apparent diffusion coefficient of slow diffusion directed perpendicular to the fibers was higher with significance in MS) compared to conventional mono-exponential fit ADC.

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