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Abstract #2673

Neurite Orientation Dispersion and Density Imaging (NODDI) Adds Biophysical Insight of White Matter Microstructural Injury in Neonatal Encephalopathy

Peter J Lally 1 , Hui Zhang 2 , Shreela S Pauliah 1 , David L Price 3 , Alan Bainbridge 3 , Ernest B Cady 3 , Seetha Shankaran 4 , and Sudhin Thayyil 1

1 Perinatal Neurology and Neonatology, Imperial College London, London, United Kingdom, 2 Centre for Medical Image Computing, University College London, London, United Kingdom, 3 Medical Physics and Biongineering, University College London Hospitals NHS Trust, London, United Kingdom, 4 School of Medicine, Wayne State University, Detroit, Michigan, United States

Descriptors of white matter (WM) diffusivity correlate with adverse neurological outcome in neonatal encephalopathy (NE). WM integrity measures derived from clinical diffusion tensor imaging are difficult to interpret in terms of microstructural morphology. We aimed to examine changes in WM microstructure associated with NE, and relate these to tangible biophysical models by fitting single-shell DTI data to the neurite orientation dispersion and density imaging (NODDI) model. Single subject maps of NODDI indices were noisy, but cohort-averaged maps (n=31) enabled characteristic changes in WM fractional anisotropy and radial diffusivity to be related to a possible reduction in neurite density.

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