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Abstract #2666

Phantomas: a flexible software library to simulate diffusion MR phantoms

Emmanuel Caruyer 1 , Alessandro Daducci 2 , Maxime Descoteaux 3 , Jean-Christophe Houde 3 , Jean-Philippe Thiran 2 , and Ragini Verma 1

1 Section of Biomedical Image Analysis, Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States, 2 Signal Processing Laboratory 5, cole Polytechnique Fdrale de Lausanne, Lausanne, Vaud, Switzerland, 3 Sherbrooke Connectivity Imaging Lab, Universit de Sherbrooke, Sherbrooke, Qubec, Canada

We introduce Phantomas, an open-source software library to create realistic phantoms in structural and diffusion MRI. The software allows evaluation of each step of a tractography processing pipeline: acquisition design, preprocessing, local reconstruction and tractography algorithm. By starting from a ground truth configuration of fiber bundle geometries, Phantomas provides a basis to quantitatively evaluate connectivity analyses, using metrics based on successful reconstruction of the true connectivity profile. Complementarily, local metrics can be computed to measure the accuracy of local reconstruction methods. We demonstrate that user can easily create crossing, kissing and bending fiber configurations, leading to complex intravoxel diffusion profiles.

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