Regional change in DTI parameters due to scanner upgrade: effects on TBSS and ROI analysis
Petra Pouwels 1 , Frederik Barkhof 2 , Rudolf Verdaasdonk 1 , and Joost Kuijer 1
Physics & Medical Technology, VU University
Medical Center, Amsterdam, Netherlands,
and Nuclear Medicine, VU University Medical Center,
Regional changes in DTI parameters were observed in
healthy volunteers at 3T after a hardware upgrade.
Pairwise comparison (mimicking longitudinal studies)
showed significant FA differences in 26.7% of the WM
skeleton, and in all diffusivities, especially in the
body of the corpus callosum. Unpaired comparison
(mimicking cross-sectional studies) still showed FA
differences in 5.5% of the skeleton. A change in
gradient system and related eddy-current behaviour might
be the cause of the observations. No pairwise
differences were observed in repeated measurements on
the same scanner. These results emphasize the need to
take scanner upgrade into account in the study design.
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