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Abstract #2638

Reproducibility and Normal Values of Microscopic Diffusion Anisotropy Measures and Their Variation in Healthy Volunteers

Marco Lawrenz 1,2 and Juergen Finsterbusch 1,2

1 Department of Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Hamburg, Hamburg, Germany, 2 Neuroimage Nord, University Medical Centers Hamburg-Kiel-Luebeck, Hamburg-Kiel-Luebeck, Hamburg-Kiel-Luebeck, Germany

Double-wave-vector diffusion-weighting (DWV) experiments with two weighting periods applied successively offer access to microscopic tissue properties, e.g. the diffusion anisotropy present on a microscopic scale. This anisotropy is independent of the axon orientation distribution and, thus, may better reflect axon integrity than measures derived from DTI. To investigate whether measures of th microscopic diffusion anisotropy, e.g. the so-called MA index, are feasible for application in clinical or neuroscientific research, normal values in white matter and their variation within a group of healthy volunteers as well as their reproducability within and between sessions are determined.

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