Meeting Banner
Abstract #2633

Oscillating Gradient Diffusion MRI in the ex-vivo prostate to assess ADC behavior at small diffusion times

Andre Bongers 1 , Aritrick Chatterjee 2 , Geoffrey Watson 3 , and Roger Bourne 4

1 Mark Wainwright Analytical Centre, University of New South Wales, Sydney, NSW, Australia, 2 University of Sydney, Sydeny, NSW, Australia, 3 Royal Prince Alfred Hospital, Sydney, NSW, Australia, 4 University of Sydney, Sydney, NSW, Australia

As DWI is able to sensitively sample cellular changes in tissues the method is a promising biomarker for prostate cancer detection. Standard PGSE methods usually sample ADCs in the long diffusion time regime, meaning that ADC quantification is affected by cellular restrictions from multiple scales. This study explores the ability of oscillating gradient DWI (OGSE) methods to detect subcellular changes in fixed and unfixed ex-vivo prostate tissue at high magnetic field. Our findings show that -in the short diffusion time regime- ADC-diffusion-time behavior depends significantly on prostate tissue type and suggest that that prostate cancer induces intracellular structure changes.

This abstract and the presentation materials are available to members only; a login is required.

Join Here