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Abstract #2624

Microstructural characterisation of normal and malignant human prostate tissue with VERDICT-MRI

Eleftheria Panagiotaki 1 , Rachel W Chan 2 , Nikolaos Dikaios 2 , Hashim U Ahmed 3 , David Atkinson 2 , Shonit Punwani 2 , David J Hawkes 1 , and Daniel C Alexander 1

1 Centre for Medical Image Computing, University College London, London, London, United Kingdom, 2 Centre for Medical Imaging, University College London, London, United Kingdom, 3 Research Department of Urology, Div of Surgery & Interventional Sci, University College London, London, United Kingdom

This study utilised diffusion-weighted MRI to probe in vivo the microstructure of benign and cancerous prostate tissue non-invasively. For this purpose, a mathematical model was employed to capture the Vascular, Extracellular and Restricted DIffusion for Cytometry in Tumours (VERDICT). We demonstrate the technique in patients with prostate cancer of Gleason score 7 (3+4) in the peripheral zone (all imaged before undergoing biopsy). Experiments using the VERDICT model identified a significant increase in vascular volume in the tumour regions. The standard apparent diffusion coefficient (ADC) and intravoxel incoherent motion (IVIM) models failed to detect any significant differences between benign and tumour areas.

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