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Abstract #2621

Bayesian Estimation of the Axonal Diffusion Coefficients in Brain White Matter

Enrico Kaden 1 , Frithjof Kruggel 2 , and Daniel C. Alexander 1

1 Centre for Medical Image Computing, University College London, London, United Kingdom, 2 Department of Biomedical Engineering, University of California, Irvine, Irvine, CA, United States

Diffusion MR imaging has enabled us to study the geometry of white matter in the individual human brain noninvasively. The present work aims to quantify the voxel-averaged diffusion coefficients parallel to an axon and perpendicular to it without any prior knowledge about how the axons are oriented within a voxel because the fiber orientation distribution is typically not known in advance. The axonal water diffusivity reflects the fiber microanatomy such as the axon diameter, the myelination, and the interaxonal space.

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