Abstract #2613
High resolution OGSE DTI of ex vivo mouse brain to investigate the frequency-dependence of the apparent diffusion tensor in cerebellar white matter
Jeff Kershaw 1 , Sayaka Shibata 1 , Ichio Aoki 1 , Takayuki Obata 2 , and Hiroshi Ito 1
1
Molecular Imaging Centre, National Institute
of Radiological Sciences, Chiba, Japan,
2
Research
Centre for Charged Particle Therapy, National Institute
of Radiological Sciences, Chiba, Japan
An earlier study of ex vivo mouse brain was the first to
demonstrate that increasing the MPG frequency strongly
enhanced the mean diffusivity in the cerebellar granule
cell layer of the cerebellum. There was also a much
weaker increase for the cerebellar molecular layer.
However, no data was presented for the cerebellar white
matter (CBWM), which is odd because investigating the
diffusion characteristics of white matter is one of the
main targets of diffusion-weighted MRI. The present
study was performed to address this omission and report
the first quantitative OGSE DTI measurements for mouse
CBWM.
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