Meeting Banner
Abstract #2613

High resolution OGSE DTI of ex vivo mouse brain to investigate the frequency-dependence of the apparent diffusion tensor in cerebellar white matter

Jeff Kershaw 1 , Sayaka Shibata 1 , Ichio Aoki 1 , Takayuki Obata 2 , and Hiroshi Ito 1

1 Molecular Imaging Centre, National Institute of Radiological Sciences, Chiba, Japan, 2 Research Centre for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba, Japan

An earlier study of ex vivo mouse brain was the first to demonstrate that increasing the MPG frequency strongly enhanced the mean diffusivity in the cerebellar granule cell layer of the cerebellum. There was also a much weaker increase for the cerebellar molecular layer. However, no data was presented for the cerebellar white matter (CBWM), which is odd because investigating the diffusion characteristics of white matter is one of the main targets of diffusion-weighted MRI. The present study was performed to address this omission and report the first quantitative OGSE DTI measurements for mouse CBWM.

This abstract and the presentation materials are available to members only; a login is required.

Join Here