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Abstract #2607

Measurement of axon diameter and axon density of the corticospinal tract in idiopathic normal pressure hydrocephalus by q-space imaging

Kouhei Kamiya 1,2 , Masaaki Hori 1 , Yuriko Suzuki 3 , Atsushi Nakanishi 1 , Issei Fukunaga 1 , Koji Kamagata 1 , Mariko Yoshida 1 , Masakazu Miyajima 4 , Hajime Arai 4 , and Shigeki Aoki 1

1 Department of Radiology, Juntendo University School of Medicine, Bunkyo, Tokyo, Japan, 2 Deparment of Radiology, Graduate School of Medicine, the University of Tokyo, Bunkyo, Tokyo, Japan, 3 Philips Electronics Japan, Ltd, Tokyo, Japan, 4 Department of Neurosurgery, Juntendo University Graduate School of Medicine, Bunkyo, Tokyo, Japan

The gait disturbance is a characteristic treatable symptom of idiopathic normal pressure hydrocephalus (iNPH), though the etiology is not clear yet. This study evaluated axon diameter and axon density of the cortico-spinal tract (CST) in iNPH patients by using two-component low-q fit method of q-space imaging. Compared with controls, patients with iNPH had increased axon density of the CST running near the lateral ventricle, whereas the axon diameter was not altered. The present results suggest the idea that the gait disturbance in iNPH is not due to irreversible axonal damage, but results from compression and/or stretching of neural tracts.

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