An accurate and precise new method for measuring kurtosis of intravoxel incoherent motion

Recently, clinical usefulness of diffusional kurtosis has been reported, e.g., for distinguishing benign from malignant prostate tissues. Measured diffusional kurtosis must contain a systematic error owing to two factors: approximations in method for kurtosis measurement and perfusion. The error is unclear because the true value is still unknown. Clarifying the error is important to improve the kurtosis measurement method and explore its clinical significance. We first investigate the systematic error in measured kurtosis by numerical experiments. We then develop a new method for measuring kurtosis. Finally, we assess clinical significance of the kurtosis obtained by the new method with simulation.

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