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Abstract #2587

The Variation of MAP-MRI derived Parameters along White Matter Fiber Pathways in the Human Brain

Alexandru V Avram 1 , Alan S Barnett 1,2 , and Peter J Basser 1

1 Section on Tissue Biophysics and Biomimetics, NICHD, National Institutes of Health, Bethesda, MD, United States, 2 The Henry Jackson Foundation, Bethesda, MD, United States

Scalar indices derived from diffusion weighted MR images (DWIs) provide invaluable clinical information for characterizing changes in brain microstructure and cytoarchitecture. In this study we apply the recently developed mean apparent propagator (MAP)-MRI framework to quantify the brain diffusion properties in healthy volunteers and describe and interpret the variation of scalar descriptors of the MAP (such as zero-displacement probability, non-gaussianity and propagator anisotropy) along the major white matter fiber pathways and discuss the clinical significance of our findings.

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