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Abstract #2541

Ultrahigh-field quantitative MR imaging of ex vivo intracranial atherosclerotic plaques

Anita A. Harteveld 1 , Nerissa P. Denswil 2 , Jeroen C.W. Siero 1 , Jaco J.M. Zwanenburg 1,3 , Aryan Vink 4 , Wim G.M. Spliet 4 , Nikki Dieleman 1 , Peter R. Luijten 1 , Mat J.A.P. Daemen 2 , Jeroen Hendrikse 1 , and Anja G. van der Kolk 1

1 Department of Radiology, University Medical Center Utrecht, Utrecht, Netherlands, 2 Department of Pathology, Academic Medical Center, Amsterdam, Netherlands, 3 Image Science Institute, University Medical Center Utrecht, Utrecht, Netherlands, 4 Department of Pathology, University Medical Center Utrecht, Utrecht, Netherlands

Intracranial atherosclerosis is one of the most important causes of ischemic stroke and transient ischemic attack (TIA). In the recent years, several intracranial vessel wall imaging techniques using (ultra)high-field magnetic resonance imaging (MRI) have emerged for the evaluation of atherosclerotic vessel wall lesions. However, a thorough correlation of MRI results of intracranial plaques with histopathology is still lacking. Therefore, a multi-contrast ultrahigh-resolution MRI protocol at 7T was developed for ex vivo quantitative intracranial atherosclerotic plaque characterization. Together with the results of the corresponding histological data, a proper correlation of the MRI findings with the underlying pathology may be performed.

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