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Abstract #2531

Voxel anisotropy in carotid MRI: impact on fibrous cap thickness and lipid-rich necrotic core size measurements of atherosclerotic plaques

Harm Nieuwstadt 1 , Zaid Kassar 1,2 , Aad van der Lugt 2 , Ton van der Steen 1,3 , Marcel Breeuwer 4,5 , and Frank Gijsen 1

1 Biomedical Engineering, Erasmus MC, Rotterdam, Zuid-Holland, Netherlands, 2 Radiology, Erasmus MC, Rotterdam, Zuid-Holland, Netherlands, 3 Imaging Science and Technology, Delft University of Technology, Delft, Zuid-Holland, Netherlands, 4 Philips Healthcare, Best, Noord Brabant, Netherlands, 5 Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Noord Brabant, Netherlands

We employed MRI simulations to quantify the influence of slice thickness (i.e. voxel anisotropy in the slice-select direction) for carotid MRI of atherosclerotic plaques. We simulated a clinically applied 2D T1 weighted sequence and varied the slice thickness. Five realistic 3D plaque models were created from histological data. We found significant improvements in FC thickness measurement error when using thinner slices, but less to no improvements in LRNC size measurements. Our study indicates that for carotid MRI, the use of anisotropic voxels can be permitted for specific applications. However, the use of thinner slices improves minimum FC thickness measurements.

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