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Abstract #2523

Optimized threshold selection for automatic carotid intraplaque hemorrhage detection in magnetization-prepared rapid acquisition gradient-echo (MP-RAGE) MRI with histology validation

Jin Liu 1 , Niranjan Balu 1 , Daniel S. Hippe 1 , Marina S. Ferguson 1 , Vanesa Martinez-Malo 1 , J. Kevin DeMarco 2 , David C. Zhu 2 , Hideki Ota 3 , Jie Sun 1 , William S. Kerwin 1 , Thomas S. Hatsukami 1 , and Chun Yuan 1

1 University of Washington, Seattle, WA, United States, 2 Michigan State University, MI, United States, 3 Tohoku University Hospital, Sendai, Japan

Intraplaque hemorrhage (IPH), a critical factor in atherosclerosis destabilization, can be detected as a hyperintense area in magnetization-prepared rapid acquisition gradient-echo (MP-RAGE) MR images. Currently the threshold to define hyperintensity is arbitrarily chosen relative to surrounding muscle without histology validation.. In this study, optimized thresholds for carotid IPH detection in MP-RAGE images were obtained using histology as golden standard, providing an automatic and effective IPH detection method. Furthermore, results showed that the IPH areas measured in MRI using the optimized thresholds highly correlated with those measured in histology.

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