A MRI-based framework for the analysis of aortic morphometry: a first application to diastolic dysfunction.
Orestis Vardoulis 1 , Diego Gallo 2 , Davide Piccini 3,4 , Pierre Monney 5 , Umberto Morbiducci 2 , Gabriele Bonanno 3 , Nikos Stergiopulos 1 , and Juerg Schwitter 5
LHTC-IBI-STI, EPFL, Lausanne, Vaud,
Department, Politecnico di Torino, Piemonte, Italy,
for Biomedical Imaging (CIBM), Department of Radiology,
University Hospital (CHUV) and University of Lausanne (UNIL),
Healthcare IM BM PI, Advanced Clinical Imaging
Technology, Vaud, Switzerland,
de la RM cardiaque, CHUV, Vaud, Switzerland
We retrospectively analysed 3D MRA datasets of thoracic
anatomy for 10 subjects with suspected diastolic
dysfunction and a control group with normal LV geometry
and function. The aim was to identify the aortic
morphological features that differ significantly between
healthy and diseased subjects. Initially, the aortic
geometries were segmented. Centerlines were extracted,
the dihedral angles were estimated and the corresponding
vectors of curvature, torsion and cross sectional area
were calculated. The non-parametric Mann Whitney U test
showed that the dihedral angle and torsion amplitude
differed significantly in the region between the aortic
valve and the ascending aorta.
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