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Abstract #2509

A MRI-based framework for the analysis of aortic morphometry: a first application to diastolic dysfunction.

Orestis Vardoulis 1 , Diego Gallo 2 , Davide Piccini 3,4 , Pierre Monney 5 , Umberto Morbiducci 2 , Gabriele Bonanno 3 , Nikos Stergiopulos 1 , and Juerg Schwitter 5

1 LHTC-IBI-STI, EPFL, Lausanne, Vaud, Switzerland, 2 Mechanics Department, Politecnico di Torino, Piemonte, Italy, 3 Center for Biomedical Imaging (CIBM), Department of Radiology, University Hospital (CHUV) and University of Lausanne (UNIL), Vaud, Switzerland, 4 Siemens Healthcare IM BM PI, Advanced Clinical Imaging Technology, Vaud, Switzerland, 5 Centre de la RM cardiaque, CHUV, Vaud, Switzerland

We retrospectively analysed 3D MRA datasets of thoracic anatomy for 10 subjects with suspected diastolic dysfunction and a control group with normal LV geometry and function. The aim was to identify the aortic morphological features that differ significantly between healthy and diseased subjects. Initially, the aortic geometries were segmented. Centerlines were extracted, the dihedral angles were estimated and the corresponding vectors of curvature, torsion and cross sectional area were calculated. The non-parametric Mann Whitney U test showed that the dihedral angle and torsion amplitude differed significantly in the region between the aortic valve and the ascending aorta.

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