Abstract #2486
Analysis of Hemodynamic Parameters for Symptomatic Marfan Syndrome Patients by Phase-Contrast MRI
Hung-Hsuan Wang 1 , Hsin-Hui Chiu 2 , Shih-Han Hung 3 , Wen-Yih Isaac Tseng 4 , and Hsu-Hsia Peng 1
1
Biomedical Engineering and Environmental
Sciences, National Tsing Hua University, Hsinchu,
Taiwan,
2
Pediatrics,
Taipei Medical University Hospital, Taipei, Taiwan,
3
Graduate
Institute of Biomedical Electronics and Bioinformatics,
National Taiwan University, Taipei, Taiwan,
4
Center
for Optoelectronic Biomedicine, College of Medicine,
National Taiwan University, Taipei, Taiwan
One of the most life-threatening complications for
Marfan syndrome (MFS) patients is aortic dissection or
rupture. Medical therapy to reduce the rate of aortic
dilatation and risk of dissection, once MFS has been
diagnosed, is now advocated. The purpose of this study
is to analyze regional wall shear stress (WSS) and
oscillatory shear index along the aorta of MFS patients
with usage of noninvasive phase-contrast MRI. The values
of WSS were significant lower in MFS patients. Regional
distribution of WSSaxial displayed the chaotic flows in
specific sites of the aorta, which may indicate
potential sites with high risk of dissection.
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